The Whispers of Biology

  I had to analyze data from 96- or 384-well plates — each exported as a CSV file with thousands of rows. Sounds familiar? Yes! 96 or 384 wells — the well plates from the wet lab. My data came from 2D cell culture imaging, where I had to analyze single-cell information. I opened each file, searched for specific values, and repeated the same thing again and again. What I faced were: - Finger pain 😂 - Human weakness → human error after half a day of doing this - Forgetting to save → all work gone - Changing cut-offs → meant redoing everything from the start (and you know how often supervisors change them!) I realized all of this was just repetition. I knew every step — I just had to do it again for every well (or many plates). So I told my supervisor I wanted to use coding/programming to automate it. His answer? No. He wanted me to do it manually — “by eyes” — to get results faster. But I believed I could do more. So I decided to learn coding (R) secretly. I didn’t tell him — I ...

  Let’s break it down scene by scene so it’s easy to follow. Ready? Let’s roll! 🎬 🎬 Scene 1: The War Inside the Body Inside our body lives a massive army of dinosaur soldiers —our immune system— guarding the city of “Bodyville” from enemies like viruses, bacteria, and cancer cells. They’re always ready for battle— but here’s the catch… sometimes, these dino-soldiers go berserk! 😱 They start firing at everything in sight— even innocent citizens like the liver, eyes, or skin. And that’s how autoimmune diseases begin— when your body’s own army can’t tell friend from foe. 🦕 Scene 2: Enter the Boss – T-Rex the Peacemaker In 2025 , the Nobel Prize in Physiology or Medicine 🏅 was awarded to Mary Brunkow , Fred Ramsdell , and Shimon Sakaguchi for discovering the Regulatory T cell (Treg) — the real-life T-Rex boss of the immune army! 🦖 Yes, this T-Rex doesn’t roar to fight — it roars to calm the troops down . 🧠 Scene 3: The Birth of the T-Reg Unit Tregs are t...

    🔥 When the “Hashira of Demon Slayer” face off against “Cancer Demons”… What real-world treatments do they represent? ✨ Hashira × Cancer-killing strategies 🌊 Giyu – Water → Chemotherapy 👉 Wide-flow attack across the battlefield, wiping out many enemies but sometimes hitting teammates too (side effects). 🔥 Rengoku – Flame → Radiotherapy 👉 Burns a precise target, breaking DNA apart — best for “pinpoint strikes.” 🦋 Shinobu – Insect → Targeted Therapy / Monoclonal Antibody 👉 Sharp, needle-like poison aiming at “molecular weak points” (e.g., HER2, EGFR). Example: Trastuzumab (HERDARA) locks onto HER2 and blocks growth signals. 🌫️ Tokito – Mist → Nanomedicine / Drug Delivery 👉 Tiny particles sneak through defenses, carrying drugs to unlock destruction at the target. 💥🎶 Uzui – Sound → Surgery 👉 Timed, explosive precision — removing the “big boss” tumor straight from the field. 🐍 Obanai – Serpent → Immunotherapy (Checkpoint Inhibitors / ADCC) 👉 Releases...

 R.I.P. Prof. David Baltimore Nobel Laureate in Physiology/Medicine (1975) — discoverer of the enzyme Reverse Transcriptase (RT) in 1970, at just 37 years old. This enzyme has been in every high-school biology textbook, yet many of us forget how revolutionary its discovery was. It changed the way we understand life, disease, and treatment. At that time, the Central Dogma was simple: DNA → RNA → Protein. But RT overturned the dogma: RNA → DNA. A paradigm shift. Baltimore’s experiment explained how viruses could integrate their genetic material into the host DNA. Later, this became central to our understanding of HIV, cancer biology, and the development of therapies. His discovery also sparked the golden era of viral oncogenes — genes like src and myc carried by viruses that could integrate into human DNA and trigger cancer. I was fortunate to join a seminar earlier this year where Prof. Baltimore gave a keynote talk at Cold Spring Harbor Laboratory (Cancer Genetics: History & Co...

 💊 The Infinity Cancer Drug Factory 🏯✨   Pharmacy students don’t just learn about medicines — we also have to design factory layouts … even though most of us can’t use AutoCAD properly 😂 Designing a pharmaceutical plant layout is never simple. 🏭 For a regular drug factory , you already need a complex flow to separate cleanroom grades and prevent contamination. ⚠️ For chemotherapy drugs (cytotoxic) , the complexity increases — you must protect workers and contain hazardous substances. 🧬 For biologics , you add another layer: biosafety . It becomes so complicated that it feels like Infinity Castle from Demon Slayer — you can enter, but finding the way out is impossible 😅. 💡 Back in pharmacy school, we had to design plant layouts too: Some friends got simple factories (like paracetamol) → easy task 😌 My group drew a chemotherapy factory → endless books and regulations 📚 My close friend got a vaccine factory → even harder, with design + legal compliance ...

🐧 Penguin → the Linux mascot. Unix command line is like a rare language. I chose to learn it after Prof. Xiaole Shirley Liu taught me in STAT115, and with Tommy’s encouragement. Many said: “Just use no-coding tools, it’s easier.” Yes, that’s possible — but in the long run, harder paths build stronger skills. Today, I’m grateful I took that way. ❤️ Iron Man armor → transformation is never easy. Like Iron Man, the process is tough, but it makes you stronger — a scientist’s version of becoming a superhero. 🧪💻 Hybrid identity → test tube in one hand, laptop in the other. This penguin represents my journey as a hybrid wet–dry lab researcher. ⸻ 💡 Transformation is hard, but that’s what makes it powerful. You can do it too — keep going! 🚀 ⸻ Build a greater science together with me! 🌸 Thai language: NO CANCER FB page / Blogger https://lnkd.in/gQa3apBc 🧬 English language: The Whispers of Biology (LinkedIn / Blogger) https://lnkd.in/gRTnrpRz ⸻ #TheWhispersOfBiology #HybridResearcher #Data...